Preparation and Quality Control of Clobetasol Propionate Gel
- VernacularTitle:丙酸氯倍他索凝胶剂的制备与质量控制
- Author:
Aijun ZHANG
;
Xinghua LI
;
Yitao WANG
- Publication Type:Journal Article
- Keywords:
clobetasol propionate;
gel;
quality control
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare clobetasol propionate gel and to establish a method for its quality control METHODS:With carbamer941 as veihele,the 0 05% clobetasol propionate gel was prepared;An ultraviolet spectrophotometry at 241nm for the determination of clobetasol propionate in gel was established RESULTS:The calibration curve of clobetasol propionate was linear in the concentration range of 6～24?g/ml,A=0 0 324C-0 0 863(n=3),r=0 9 999 The average recovery rate was 99 44%(n=5),RSD=1 14% CONCLUSION:The preparation of clobetasol propionate gel was simple,its quality was stable;The method of quality control was rapid and accurate
