Clinical Study on Naloxone in Treatment of 25 Patients With Acute Craniocerebral Trauma
- VernacularTitle:盐酸纳洛酮(金尔伦)治疗急性颅脑损伤25例疗效观察
- Author:
Zhixiong HUANG
;
Ying DENG
;
Guoliang GUAN
;
Qiming LIN
;
Junfang ZHANG
- Publication Type:Journal Article
- Keywords:
naloxone;
craniocerebral injury;
ET;
brain ultrasonography;
brain electroencephalography
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the therapeutic effect of naloxone early to administer on acute craniocerebral trauma ME_THODS:46 patients with acute craniocerebral trauma were randomly divided into two groups:Besides routine treatment,25 patients were treated with naloxone in a dose of 8mg q d ,21 patients did not treated with naloxone The GCS score,plasma ET levels,transcranial Doppler(TCD),and electroencephalogram(EEG) were measured 1 day,7 days after the administration The results were analyzed statistically RESULTS:In treatment group,GCS score was obviously improved,the level of ET in plasma was reduced;brain vasospasm incidence rate was lower and abnormal rate of EEG was lower in comparison with those in control group As a result,the detecting indices in treating group were superior to those in the control group(P
