Caspase 3 Activity of Ischemia Reperfusion Injury in Rats and The Protective Mechanism of Ischemic Preconditioning
- VernacularTitle:鼠肝缺血再灌注损伤Caspase3活性变化及缺血预处理的保护机制
- Author:
Nengzhi CHEN
;
Xinsheng LU
- Publication Type:Journal Article
- Keywords:
Liver;
Ischemia-reperfusion;
Ischemic preconditioning;
Caspase 3;
Apoplosis;
Rat
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate Caspase 3 activity in the ischemia reperfusion injury in rats and the protective effect of ischemic preconditioning and its possible mechanism.Methods 30 rats were randomly assigned to ischemia reperfusion (IR) group, ischemic preconditioning(IP) group,sham-operation(S)group.The serum aspartate transaminase (AST),alanine transaminase(ALT),liver caspase 3 activity,and apoptosis index(AI) of hepatocytes were examined in the three groups at 3 hours after repersusion.Results The serum AST,ALT,liver caspase 3 activity and apoptotic hepatocytes were significantly higher in both IP and IR groups than those in S group(P
