Calcitonin Gene-related peptides and Vasoactive Intestinal Peptide in Plasma and Lesion of Patients with Alopecia Areata
- VernacularTitle:斑秃患者血浆和皮损中降钙素基因相关肽、血管活性肠肽的研究
- Author:
Fengli XIAO
;
Shunqiang GAO
;
Guishen YAO
;
Yanqing GAO
;
Yuanzhu LIN
- Publication Type:Journal Article
- Keywords:
Alopecia areata;
Calcitonin gene-related peptide;
Vasoactive intestinal peptide
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of calcitonin gene-related peptide(CGRP)and vasoactive intestinal peptide(VIP)in the pathogenesis of alopecia areata(AA).Methods Radioimmunoassay(RIA)was used to measure the levels of CGRP and VIP in plasma from30patients with AA and20normal controls.Immunohistochemistry was employed to detect the expression of CGRP and VIP in lesions of21patients with AA and16normal scalps.Results①The plasma levels of CGRP in progressing stage of AA(142.63?67.95pg/mL)were significantly lower than those in stable stage of AA(197.33?67.15pg/mL)and in normal controls(188.40?72.95pg/mL).②The plasma levels of VIP in progressing stage of AA(105.94?55.42pg/mL)were significantly lower than those in stable stage of AA(156.86?47.37pg/mL)and in normal controls(176.44?84.70pg/mL).③The expression of CGRP and VIP was significanly decreased in lesions of AA than that in normal scalps.Conclusion These findings indicate that CGRP and VIP may play a role in the pathogenesis of alopecia areata.
