Clinical and In Vitro Study of Viaminate in Acne
- VernacularTitle:维胺酯治疗痤疮的疗效观察及实验研究
- Author:
Yintao LI
;
Hong CHEN
;
Shiyin LI
;
Hongqing CHEN
;
Weining HUANG
;
Miaojian WAN
;
Xiangyang SU
;
Sulian YANG
;
Fengxian OU
- Publication Type:Journal Article
- Keywords:
Vitamine A acid;
Acne,vulgaris;
Receptor,androgen
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of oral viaminate(a vitamine A acid derivative)on acne and its effect on the expression of androgen receptor.Methods Two hundred and eigh-teen patients with acne were allocated to treatment group and control group at random:treatment group was treated by oral viaminate;control group was treated by oral minocycline.The treatment lasted for four weeks.The effect of viaminate on the expression of androgen receptor was studied in COLO-16cells in vitro by using Northern blot or Western blot.Results The therapeutic effect of oral viaminate in treatment group was higher than that in control group(P
