Inhibition of electrolyte transport in isolated guinea-pig ileum by berberine
- VernacularTitle:小檗碱对豚鼠回肠电解质转运影响的研究
- Author:
Xiaodong HUANG
;
Hesheng LUO
;
Baoping YU
;
Jiwang CAO
;
Jianqin TANG
- Publication Type:Journal Article
- Keywords:
Berberine;
Cholera toxin;
Intestinal mucosa;
Electrolyte transport
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of berberine (Ber) on ion transport and hypersecretion induced by cholera toxin(ChT) in ileum and its mechanism. METHODS: Ussing Chamber technique was used to measure the potential difference(PD), short-circuit current(SCC), and the resistance(R) in isolated guinea-pig ileum. The effects of Ber on PD, SCC and R in glucose Tyrode solution or glucose-free Tyrode solution were examined. The secretory diarrhoea model was made by ChT to investigate the effects of ChT and ChT+Ber on PD, SCC and R. RESULTS: (1)The PD and SCC were decreased in glucose Tyrode solution by the Ber added in mocosal side or in serosal side in ileum of normal guinea-pig and which was with secretory diarrhoea ( P
