Inhibitory effects of LDL-ACM complex on subcutaneous implanted tumors in nude mice
- VernacularTitle:LDL-ACM复合物对裸鼠皮下移植瘤靶向抑制作用的初步研究
- Author:
Anli JIANG
;
Ludong KANG
;
Chunhua ZHAO
;
Wenxiang BI
;
Xiaoyan HU
;
Feng KONG
;
Songde XU
- Publication Type:Journal Article
- Keywords:
Lipoproteins, LDL;
Aclarubicin;
Mice, nude;
Stomach neoplasms cell lines
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: In order to evaluate the applicable value of LDL as a targeted vehicle for chemotherapeutic agents, we investigated and compared the inhibitory effects of LDL-ACM complex and free ACM on nude mice's subcutaneous implanted tumors derived from gastric cancer cell lines, SGC-7901 and NKM-45. METHODS: LDL-ACM complex was prepared and the tumor model of nude mice was established by subcutaneous implantation of SGC-7901 and NKM-45. Then, the groups of nude mice developed subcutaneous implanted tumors were received either LDL-ACM complex or free ACM. Subsequently, the tumor size, weight and leukemia cell counts were measured and the rates of tumor-inhibition and the survival were compared among the groups. RESULTS: The inhibitory effects of LDL-ACM complex on the tumors, especially on SGC-7901 implanted tumors were much more obvious than that of free ACM. It was also indicated that the action of LDL-ACM complex was mediated by LDL receptor. CONCLUSION: These results showed that LDL-ACM complex had significant inhibitory effects on the implanted tumors and the effect might be mediated by LDL receptor.
