Role of glucocorticoid receptor in hepatic injury in early stage after severe multiple injury
- VernacularTitle:糖皮质激素受体在严重多发伤后早期继发性肝损伤中的作用研究
- Author:
Donglin LUO
;
Jihong ZHOU
;
Baohua LIU
;
Xiankai HUANG
;
Dawei LIU
;
Renping XIONG
;
Bo ZHANG
- Publication Type:Journal Article
- Keywords:
Multiple trauma;
Receptors, glucocorticoid;
Liver;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the functions of GR in the course of hepatic secondary injury after severe multiple injury. METHODS: Rat model was produced by adopting severe thoracic impact injury accompanied with mono-side femur fracture, and glucocorticoid receptor was blocked before severe multiple injury. Hepatic macropathology and alterations under light microscope were examined. Maximal binding volume of glucocorticoid receptor (GR) in hepatic tissue was assayed by radio-ligand binding assay and protein content was assayed by Western blot. RESULTS: Maximal binding volume and protein content of GR were gradually decreased in hepatic tissue after severe multiple injury, obviously lower than that in normal control at 4 h after trauma ( P
