Role of antibody dependent cell-mediated cytotoxicity effect of immunocytes in asthma
- VernacularTitle:抗体依赖的细胞介导的细胞毒效应在哮喘发病机制中的作用
- Author:
Suxian HU
;
Jin HUANG
;
Zehua DONG
- Publication Type:Journal Article
- Keywords:
Asthma;
Macrophages;
Dendritic cells;
B-lymphocytes;
T-lymphocytes;
Antibody dependent cell-mediated cytotoxicity;
Mice
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To further investigate the mechanism of bronchial asthma.METHODS: Experimental asthma mouse model was established with OVA, and immunocytes were isolated, including macrophages, dendritic cells, B cells, CD3 +T cells, CD4 +T cells and CD8 +T cells from spleen. Antibody dependent cell-mediated cytotoxicity(ADCC) effects of all these cells were detected with cell proliferation and improved MTT colorimetry methods.RESULTS: The ADCC functions of M, B cells, CD3 +T cells,CD4 +T cells and CD8 +T cells from asthmatic mice were weaker than that from control ( P
