The expression of midkine(MK) in pancreatic carcinoma and its clinical significance
- VernacularTitle:中期因子在胰腺癌组织中的表达及其临床意义
- Author:
Yongliang LU
;
Xing YAO
;
Licheng DAI
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Neovascularization, pathologic;
Prognosis
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression of midkine(MK) and its relation with angiogenesis, biological features and prognosis of pancreatic carcinoma(PC).MethodsMK expression and microvessel density(MVD) were determined in 52 cases of human PC with immunohistochemistry and results were compared with pathology.ResultsMean MVD of PC was 64?18 and positive expression of MK was detected in 38 cases (73%). The positive rate of MK was significantly lower in cases of without metastasis and at early clinical stage (stageⅠ～Ⅱ) than that with metastasis and at stage Ⅲ～Ⅳ. MVD was significantly higher in MK-positive PC than in MK-negative PC (P
