Effect of thyroid hormone on serum NO concentration and iNOS activity of intestinal mucosa in septic rats
- VernacularTitle:甲状腺激素对脓毒症大鼠血清一氧化氮浓度及肠粘膜一氧化氮合酶的影响
- Author:
Jihai LIU
;
Lianyue YANG
;
Heli LIU
- Publication Type:Journal Article
- Keywords:
Thyroid hormones;
Sepsis;
Gut barrier;
Nitric oxide;
Euthyroid sick syndrome
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was to investigate the effect of exogenous thyroid hormone on serum NO and iNOS activity of intestinal mucosa in septic rats. Methods Septic model was established by cecal ligation puncture(CLP) in male SD rats. Triiodothyronine(T 3) was administered intraperitoneally to correct the low T 3 syndrome of septic rats. Blood was collected to examine serum NO and thyroid hormone concentration. Intestinal mucosa iNOS activity was assayed using immunochemical stain. Results Mortality rate in the prevention group was significantly lower than the septic group(Log rank=3.85, P
