Preventive and Therapeutic Effects of L-Arginine on Pulmonary Hypertension Induced by High Pulmonary Blood Flow Volume in Rats
- VernacularTitle:L-精氨酸防治大鼠高肺血流量所致肺动脉高压的研究
- Author:
Junbao DU
;
Jianguang QI
;
Bing WEI
;
Jian LI
- Publication Type:Journal Article
- Keywords:
L-arginine;
pulmonary hypertension;
left-right shunt
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preventive and therapeutic actions of L-arginine on pulmonary hypertension induced by high pulmonary blood flow volume.METHODS:Male SD rats were randomly divided into control group(n=6),shunt group (n=7) and shunt+L-arginine group(n=8).Abdominal aorta-inferior vena cava shunt was performed to make the blood flow from left to right,11 weeks later,mPAP was detected with right cardiac catheter;the structure of pulmonary vessels and expression of PCNA of smooth muscle cells were observed.RESULTS:The mPAP of shunt group was obviously higher than that of control(P
