Pharmacokinetics of Domestic Nimodipin Capsule in Healthy Volunteers
- VernacularTitle:口服国产尼莫地平胶囊在健康人体的药代动力学研究
- Author:
Zuhui LI
;
Min HAN
- Publication Type:Journal Article
- Keywords:
nimodipin;
pharmacokinetics;
HPLC
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics of domestic nimodipin capsule in 12 healthy volunteers.METHO_DS:An oral dose of 60mg nimodipin capsule was given to healthy volunteers,and plasma concentrations of nimodipin were determined by HPLC.The data were fitted by 3p97 program.RESULTS:The results showed that the plasma concentration-time curves profile conformed to a two compartment open model.The T1/2?,Tmax,Cmax,AUC(0～6) of this product was(2.53?1.18)h,(0.42?0.14)h,(75.41?27.65)ng/ml and (155.85?49.54)ng/(h?ml),respectively.CONCLUSION:Retention time of this preparation in healthy volunteers is short with Tmax of about 0.4h,which provides useful information for clinical practice.
