The Relationship between Gene Polymorphism of Angiotensin Ⅱ Type 1 Receptor and Plasma Endothelin in Pregnancy-induced Hypertension
- VernacularTitle:血管紧张素Ⅱ-1型受体基因多态性及血浆内皮素与妊娠高血压综合征关系的研究
- Author:
Wan SUN
;
Tao SHANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
Receptors, angiotensin;
Polymorphism (genetics);
Endothelins;
Pregnancy, complications, cardiovascular;
Hypertension
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To address angiotensin Ⅱ type 1 receptor (AT 1R) gene polymorphism and its relationship with plasma endothelin (ET) in PIH. Methods Gene polymorphism of AT 1R at site 1166 was detected with polymerase chain reaction (PCR), digestion of restriction enzyme and electrophoresis. Plasma ET was measured by radioimmunoassay. Results 1. The frequencies of genotype(AC and CC) at 1166 of AT 1R gene and C allele in PIH individuals were significantly higher than those of control group, (? 2=11.06, 9.73, respectively, P0.05). Conclusions 1. The variant (A→C) of 1166 polymorphism site of AT 1R is associated with the generation of PIH, and C allele may be a susceptible gene to PIH. 2.There is relationship between AT 1R gene and plasma ET level in PIH patients.
