Study of the Relationship Between Bcl-2/Bax Protein Expression and the Degree of Malignancy of Astrocytoma
- VernacularTitle:Bcl-2/Bax蛋白表达与星形细胞瘤恶性程度的相关性研究
- Author:
Guoxiang WU
;
Tao LI
;
Jianping WU
- Publication Type:Journal Article
- Keywords:
Astrocytoma;
Bcl-2,Bax;
Apoptosis;
Pathology
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between Bcl-2/Bax protein expression and the degree of malignancy of astrocytoma.Methods Bcl-2/Bax protein expression positive rate and apoptotic cell rate were determined using immunohistochemical technique and TUNEL, in 10 normal human brain tissues and 80 human astrocytoma specimens of differently malignant degrees confirmed by pathology separatively. Results Bcl-2/Bax protein positive expression was not found in normal human brain tissues, and apoptotic cell rate was only (0 6?0 1)%. The differences of Bcl-2/Bax protein expression positive rate and apoptotic cell rate were statistically significant in the differently malignant degrees(P
