Serum Level of Interferon-inducible T Cell Alpha Chemoattractant(I-TAC)in Patients With Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者血清?干扰素诱导的T细胞?趋化因子检测
- Author:
Lunfei LIU
;
Min ZHENG
;
Jianyou WANG
;
Zhijian YE
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Chemokines,CXC4
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relationship between serum interferon-inducible T cell alpha chemoattractant(I-TAC)levels and disease activity in patients with systemic lupus erythematosus(SLE).Methods Serum level of I-TAC was measured by sandwich ELISA.Results①Serum level of I-TAC was significantly increased in patients with SLE as compared with controls,and significantly higher in patients with active SLE than those of the inactive.Serum level of I-TAC showed significant positive correlation with disease activity,erythrocyte sedimetation rate(ESR),logarithm of serum ANA titer,and negative correlation with serum C3levels.②Serum level of I-TAC was significantly higher in patients with renal involvement than those without renal diseases.Conclusions These results suggest that I-TAC might be involved in the pathogenesis of SLE,and its serum level might be used as a good indicator for the disease activity of SLE and renal involvement.
