Dynamic expression of CD30 on peripheral blood lymphocytes in mice after a cecal ligation and puncture
- VernacularTitle:腹腔感染脓毒症小鼠外周血淋巴细胞CD30的动态表达
- Author:
Liping CHEN
;
Liang YAN
;
Haozhuang YANG
;
Suimei ZHANG
- Publication Type:Journal Article
- Keywords:
Sepsis;
Lymphocytes;
Antigens, CD30;
Flow cytometry;
Mice
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the details of Th2 cell differentiation in septic mice. METHODS: Experimental septic mice were induced by cecal ligation and puncture (CLP). The exression of CD30 on CD4 +T cells at different time after CLP were estimated by flow cytometry following three-color immunofluorescent staining.RESULTS: CD30 expression on CD4 +T cell was different at each time point. The highest expression was showed at 38 h after CLP and declined later, which matched the changes in mortality of the animals. CONCLUSION: During sepsis, differentiation of Th2 cell changed with the development of sepsis and might be associated with the severity of the disease.
