Effects of fluvastatin on the airway remodeling in a guinea pig model of asthma
- VernacularTitle:氟伐他汀对哮喘气道重塑的抑制作用及机制研究
- Author:
Liqiang SONG
;
Haowen QI
;
Yan LI
;
Bin LANG
- Publication Type:Journal Article
- Keywords:
Fluvastatin;
Asthma;
Airway remodeling;
Guinea pigs
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of fluvastatin on the airway remodeling in a guinea pig model of asthma. METHODS: Asthmatic guinea pig model was established by intraabdominal injection of ovalbumin and aluminium hydroxide and challenged with ovalbumin once every other day for 60 days. 30 guinea pigs were randomly divided into three groups: control group ( n= 10), asthma group ( n= 10) and fluvastatin plus asthma group ( n= 10) in which fluvastatin was inhaled at concentration of 0.5 g/L 30 min before every challenging. The thickness of airway smooth muscle layers of every three groups were compared after Haematin-Eosin staining by image analysis system. The level of ras mRNA in airway were examined by Dot-blot molecular hybridization. The expression levels of ras p21 were also examined by immunohistochemical technique. RESULTS: The mean thickness of airway smooth muscle in asthma group was (74 27?3 30) micrometer, greater than that of control group [(38 57?3 37) micrometer ( P
