Nerve growth factor attenuates cochlear injury induced by brain ischemia and reperfusion in rats
- VernacularTitle:神经生长因子减轻大鼠脑缺血再灌注耳蜗损伤
- Author:
Ninghua SHI
;
Zhijian ZHANG
;
Shuhong DAI
- Publication Type:Journal Article
- Keywords:
Nerve growth factors;
Brain ischemia;
Reperfusion injury;
Cochlear injury;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of nerve growth factor (NGF) on auditory and cochlear damage induced by brain ischemia and reperfusion. METHODS: The rats with brain ischemia and reperfusion were divided into two groups at random. In the experimental group, the rats were injected intramuscularly with NGF . In control group, the animals were injected with normal saline instead of NGF. Then the hearing loss and cochlear structural changes of rats in both groups were compared. RESULTS: It was found that the hearing loss of rats in NGF group were less significantly than that of control group ( P
