Role of selectin in lung injury in rabbits with diabetic ketoacidosis
- VernacularTitle:选择素在家兔糖尿病酮症酸中毒肺损伤中的作用
- Author:
Xiaojun GU
;
Jiabao CHANG
;
Xiaoyun ZHU
;
Guoqing YIN
- Publication Type:Journal Article
- Keywords:
Diabetic ketoacidosis;
Lung;
P-Selectin;
L-Selectin;
Rabbits
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of selectin on lung injury in rabbits with diabetic ketoacidosis(DKA). METHODS: 12 male New Zealand rabbits were divided into experimental group (DK groups, intravenous injection of streptozocin and alloxan monohydroate, n =6) and normal control group (received same dose of saline, n =6). After 72 hours, all the animals were killed and blood and lung tissue were collected. Blood gases, expressions of selectin-P and selectin-L were detected. RESULTS: The expression of selectin in DK group were higher than that in NS group. CONCLUSION: These results indicate that selectin expression may play an important role in lung injury during diabetic ketoacidosis.
