Changes of MDR1 and MRP gene expression in primary breast cancer after neoadjuvant chemotherapy
- VernacularTitle:乳腺癌新辅助化疗对耐药基因MDR1和MRP表达的影响
- Author:
Xinge LIU
;
Jinmin WU
;
Xiaodong SUN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Chemotherapy, adjuvant;
Drug resistance, multiple;
Multidrug resistance-associated protein
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of drug resistance genes, MDR1 and MRP, in patients with primary breast cancer after neoadjuvant chemotherapy. METHODS: MDR1 and MRP gene expression were detected by semi-quantitative RT-PCR in 20 patients with primary breast cancer before and after chemotherapy. RESULTS: Before chemotherapy, MDR1 and MRP expression could be detected in 15 cases (75%) and 18 cases (90%), respectively. After chemotherapy, expression of MDR1 was not significantly different from that before chemotherapy, but expression of MRP was significantly different from that before chemotherapy. CONCLUSION: Drug resistance gene MRP, but not MDR1 expression is enhanced in patients with primary breast cancer subjected to neoadjuvant chemotherapy.
