The inhibitory effect of aminoguanidine on periodontitis in rats
- VernacularTitle:氨基胍对牙周炎抑制作用的研究
- Author:
Shuyuan MA
;
Shiguang HUANG
;
Huadon WANG
- Publication Type:Journal Article
- Keywords:
Aminoguanidine;
Nitric oxide;
Periodontitis
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the inhibitory effect of aminoguanidine(AG) on periodontitis. METHODS: Experimental periodontitis was produced in rats by a ligature of braided silk, the NO concentration was assayed by spectrophototometry, the attachment loss of periodontium was measured by using technology for image and graphics engineering research and the histopathologic changes of periodontium were also examined under a light microscope. RESULTS: The NO concentration significantly decreased after AG treatment for 4 weeks, and the inflammation and the damages of periodontium was also reduced significantly. CONCLUSION: The inhibition of iNOS by AG may be a potential therapeutic strategy for the treatment of periodontitis.
