Inhibitory ?-adrenergic receptor in heart
- VernacularTitle:心脏的抑制性?-肾上腺素受体
- Author:
Qi XU
;
Erdan DONG
;
Kai CHEN
;
Qide HAN
- Publication Type:Journal Article
- Keywords:
Receptors, adrenergic, beta;
Heart;
Genes,structural
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
adrenergic receptor is the third subtype of ?-adrenergic receptors. The genetic structure and pharmacological property of ? 3-adrenergic receptor are markedly distinguished from ? 1-and ? 2-adrenergic receptor subtypes. Recently studies show that myocardial ? 3-adrenergic receptor mediates negative inotropic effect through Gi-protein/NO/cGMP pathway, the expression of ? 3-adrenergic receptor and negative inotropic effect mediated by ? 3-adrenergic receptor are increased in heart failure. However, because of the low expression of ? 3-adrenergic receptor in the heart, the actual pathophysiological significance of ? 3-adrenergic receptor remains unknown.
