The plasticity of hematopoietic stem cells and clinical application
- VernacularTitle:造血干细胞的可塑性及临床应用
- Author:
Yunxian CHEN
;
Xueyun ZHONG
;
Ruimin OU
- Publication Type:Journal Article
- Keywords:
Stem cells;
Plasticity;
Transdifferentiation
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Traditional concept has been that hematopoietic stem cells (HSC) are tissue-specific stem cells, which are restricted to generate the cell types of the blood and immune system. However, recent studies have shown that there is a higher plasticity of the HSC than previous expected, it can be induced to transdifferentiated into mature cells of other nonhematopoietic organs after transplantation in vivo. In this article, the recent advances in the plasticity of HSC and its potential clinical application are reviewed.
