Influence of high epidural blockade on plasma TXB_2 and 6-keto-PGF_1a level during acute myocardial ischemia- reperfusion in pigs
- VernacularTitle:高位硬膜外阻滞对猪急性心肌缺血/再灌注损伤时血浆TXB_2和6-keto-PGF_(1?)水平的影响
- Author:
Zhenming DONG
;
Yue LIU
;
Jingui GAO
- Publication Type:Journal Article
- Keywords:
Anesthesia, epidural;
Bupivacaine;
Myocardial reperfusion injury;
Thromboxane A2;
Epoprostenol
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
0. 5mV or change in color of myocardium in the ischemic area. Blood samples were taken from right atrium for determination of plasma levels of TXB2 and 6-keto-PGFla before epidural block (T0), 40 min after occlusion of coronary artery(T1 ) and 1, 3 and 5 h after reperfusion was started(T2-4 ) . Results There was no significant changes in MAP, HR and CVP in group Ⅱ while in group Ⅰ MAP decreased by 22%, HR 25% and CVP 28% after epidural block as compared with the baseline at T0 . TXB2 levels and TXB2/6-keto-PGF1a ratio increased gradually and significantly from T2-4 as compared with the baseline (T0) and those at T1 in both groups. TXB2 levels and TXB2/6-keto-PGF1a ratio were higher in group Ⅱ those in group 1111111 at T1-4 (P
