Effects of Vitamin C on Activity of Aldose Reductase in Renal Cortex of Diabetic Rats
- VernacularTitle:维生素C对糖尿病大鼠肾脏醛糖还原酶活性的影响
- Author:
Qian XIAO
;
Shuping WANG
- Publication Type:Journal Article
- Keywords:
vitamin C;
aldose reductase;
diabetic rats
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of vitamin C in different dosages on the activity of aldose reductase(AR) in renal cortex in rats with streptozotocin-induced diabetes METHODS:50 male Wistar rats(195?20)g were randomly divided into following groups:group C(control rats);group D(diabetic rats);group DT1(diabetic rats treated with vitamin C 30mg/(kg?d);group DT2(diabetic rats treated with vitamin C 90mg/(kg?d);group DT3(diabetic rats treated with vitamin C 270mg/(kg?d);The activities of AR in renal cortex and the concentrations of vitamin C in plasma and renal cortex were assayed 9 weeks after treatment RESULTS:Compared with group C,the levels of vitamin C in plasma and renal cortex decreased significantly(P
