Preparation of Inclusion Complex of Diclofenac Sodium-?-Cyclodextrin Eyedrops
- VernacularTitle:双氯芬酸钠?-环糊精包合物滴眼液的制备
- Author:
Zhiliang XU
;
Songhua YAO
;
Fang LI
;
Yuenian TANG
;
Shunguo ZHANG
;
Shuhong BU
- Publication Type:Journal Article
- Keywords:
diclofenac sodium;
?-cyclodextrin inclusion complex;
preparation
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish the preparation process of inclusion complex of diclofenac sodium-?-cyclodextrin (DS-?-CD) eyedrops METHODS:The DS-?-CD was prepared by the stir method and identified with instrumental method The content of diclofenac sodium was detected by UV,HPLC RESULTS:The inclusion ratio of DS-?-CD was(67 48?2 96)% There was no difference between diclofenac sodium and DS-?-CD in UV absorption spectrum The crystal diffraction peak of DS inclosed in DS-?-CD disappeared in X-ray CONCLUSION:The DS-?-CD can be used as eyedrops in clinical practice
