Clinical Study on Domestic Amifostine in Prevention of Nephrotoxicity of Cisplatinum
- VernacularTitle:国产氨磷汀预防顺铂肾毒性的临床研究
- Author:
Qunyou TAN
;
Desheng MENG
;
Liang CHEN
;
Wei WU
;
Jingqing ZHANG
;
Ruwen WANG
;
Yaoguang JIANG
- Publication Type:Journal Article
- Keywords:
amifostine;
cisplatinum;
nephrotoxicity
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of amifostine in prevention of nephrotoxicity induced by cisplatinum(DDP) METHODS:46 patients with malignant tumors were randomly divided into two groups:23 in chemotherapy and amifostine group(trial group)and 23 in single chemotherapy group(control group) Laboratory exmination indices such as blood routine,blood calcium,liver function,blood urea nitrogen,cretinine,and urinary ?1-microglobulin(?1-MG),albumin(Alb) and transferrin(TRF) were monitored at different time period points before and after treatment RESULTS:20 patients in each group completed the whole trial In the two periods of therapy,the peak values of ?1-MG,Alb and TRF of trial group were lower than those of control group(P
