Improvement of the Formulation of Clarithromycin Dispersible Tablets
- VernacularTitle:克拉霉素分散片的处方工艺改进
- Author:
Zhenxia XU
;
Xiaosong WU
- Publication Type:Journal Article
- Keywords:
clarithromycin;
dispersible tablet;
preparation techique;
friability
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To obtain an optimum formulation of clarithromycin dispersible tablets METHODS:The preparation process was set by way of screening formulation and a formula with substitution of LS-HPC for starch was adopted RESULTS:The results showed that the substitution of LS-HPC for starch was the most preferable formulation The hardness and the friability of the tablets were improved The external apperance of unfilled corner and torn edge of the unimproved tablets was resolved CONCLUSION:Modified formulation is favorable for improving the quality of the product
