Study on Relationship between the sharing of HLA Gene Couples with Gestational Diabetes Mellitus
- VernacularTitle:夫妇共享人类白细胞抗原DRB等位基因与妊娠期糖尿病的相关性研究
- Author:
Dianrong SONG
;
Yinglin LIU
;
Huiying ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes, gestational;
HLA-DR antigens;
Alleles
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the relationship between the HLA gene sharing of couples and gestational diabetes mellitus (GDM). Methods Thirty GDM women and their husbands served as study group, 40 normal pregnant women and their husbands were selected as control group. All pregnant women were primipara with single fetus. 5 ml cubital venous blood were taken. Genomic DNA was extracted using phenol chloroform method. HLA-DRB alleles type were determined with PCR-SSP. Results The sharing of HLA-DRB1 between couples in GDM group were 33.33%, significantly higher than that of normal pregnancy(12.50%)(P0.05). Conclusions The sharing of HLA-DRB1 between couples may inerease the risk of GDM, It suggested that placenta- and-fetus unit may play roles in GDM.
