Preliminary Observation of Apoptotic Feature of T Lymphocyte in Preterm Neonates
- VernacularTitle:早产儿T淋巴细胞凋亡特性的初步观察
- Author:
Qiuye ZHANG
;
Yanchun SHAN
;
Zengyi DONG
- Publication Type:Journal Article
- Keywords:
Apoptosis;
T-lymphocytes;
Infant, premature
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the features and its effect factors of T lymphocyte apoptosis in preterm neonates. Methods The susceptibility to apoptosis of T lymphocytes were determined in 30 full-term neonates and 19 preterm neonates by percentage calculation of apoptosis cell and DNA fragmentation analysis. The expression of CD 25 and CD 38 in peripheral blood mononuclear cells and the volume of IL-2 and IL-6 produced by lymphocytes incubated for 48 h was determined by immunofluorescence procedure and ELISA. Results T lymphocyte apoptosis was easier in preterm(27.2?2.7)%,(34.8?3.9)% than in full-term neonates(21.1?1.4)%,(27.9?2.3)% at incubating 24 h, 48 h(t=10.547,7.789;P
