Expression of bad gene in human optic nerves from traumatic atrophic eyes
- VernacularTitle:外伤性眼球萎缩眼视神经组织中bcl-2相关死亡基因bad的表达及其意义
- Author:
Dongkan LI
;
Yue SONG
;
Yue ZHANG
- Publication Type:Journal Article
- Keywords:
Bad (bcl-2 associated death) gene;
Gene, bcl-2;
Optic nerve;
Neurons;
Cell death;
Gene expression;
Immunohistochemistry
- From:
Chinese Journal of Ocular Fundus Diseases
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and its significance of bcl-2 associated death (bad) gene in human optic nerves from traumatic atrophic eyeballs. Methods The optic nerves from 8 normal human donor eyes and 31 traumatic atrophic eyes were studied by immunohistochemistry technique. Results Bad protein was positively expressed in the normal optic nerve myelin sheath and residual myelin portions of optic nerve tissues from traumatic atrophic eyes. The expression of bad protein in the residual portions of myelin sheath was stained significantly stronger than that in normal optic nerves (P0 05). Conclusion Bad might possess the function of promoting the optic nerve atrophy processes in traumatic atrophic eyes.
