Alteration of Superxied Dismutase in Diabetic Nephropathy After Type 2 Diabetes
- VernacularTitle:2型糖尿病并糖尿病肾病患者外周血超氧化物岐化酶变化
- Author:
Zhiyi YANG
;
Qihua GU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Free radical;
Superoxide dismutase
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate superoxide dismutase(SOD) activity in peripheric blood of type 2 diabetic patients(NIDDM) complicated with diabetic nephropathy(DN) and SOD alteration after insulin treatment.Methods Three groups of individuals were selected.Group A included 46 cases of NIDDM patients with DN.Group B included 43 cases of NIDDM patients with stable blood sugar.Group C included 40 cases of normal individual.Xanthine enzyme method was used to test SOD.Results The total SOD(T-SOD),CuZn-SOD,Mn-SOD in group A,B and C were 94 7?10 7,58 3?6 2 and 36 4?4 3;101 6?9 3,61 5?5 6 and 39 6?3 7;104 4?8 9,63 7?5 3 and 40 7?4 1;respectively.The SODs level in group A were significant lower than those in group B and group C(P
