The analysis of hepatic apoptosis and protection effect of Se in rats with obstructive jaundice
- VernacularTitle:梗阻性黄疸大鼠肝细胞凋亡分析及硒的保护作用
- Author:
Deen HAN
;
Zhaoyang LU
;
Sheng TAI
;
Shiguang DAN
- Publication Type:Journal Article
- Keywords:
CHOLESASIS/pathol;
LIVER/pathol;
APOPTOSIS;
SE/pharm
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the development and mechanism of hepatic cell apoptosis, and the effect of anti-apoptosis apoptosis of Se in the liver in obstructive jaundice rats. Methods(GPx) activity and (ROS) level were measured by biochemical methods,terminal-deoxynucleotidyl medicated nick end labeling (TUNEL)in different groups at different time points, and analysed by multivariate regression. Results Apoptosis cells appeared on day 3 after common bile duct(CBD) ligation ,significantly increased on day 7,reached the peak level on day 11, and began to decrease on day 14. The longer the time of obstructive jaundice in rats, the higher the level of ROS and apotosis index(AI), while the level of GPx decreased progressively. AI reached the peak 11-day after CBD ligation. Less hepatic apoptosis appeared after the rats treated with Se at every time point (P
