Change of G?q/11-mediated signal transduction pathway in aorta of spontaneously hypertensive rats
- VernacularTitle:G?q/11介导的信号转导通路在自发性高血压大鼠主动脉中的变化
- Author:
Jinyu WANG
;
Hua BAI
;
Dongqi XING
;
Jie LIU
;
Lilin WU
- Publication Type:Journal Article
- Keywords:
G?q/11;
Phospholipase C;
Aorta;
Spontaneously hypertensive rat;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of G?q/11 and phospholipase C(PLC) of the aorta and to evaluate the role of signal transduction pathway mediated by G?q/11 in the pathogenesis of spontaneous hypertension. METHODS: Blood pressure was measured by intubation of carotid, and the level of plasma angiotension Ⅱ was measured by radioimmunoassay. In addition, G?q/11 and PLC contents in aorta were determined by Western blot analysis. RESULTS: Arterial blood pressure was not changed in 4-week-old spontaneously hypertensive rats(SHR), but it was increased markedly in 12-week-old SHR. The G?q/11 expression of aorta in 4-week-old SHR was increased by 69 2%( P
