Effect of Ershen Zeshu Mixture on the peritoneal lymphatic stomata and the ascites drainage
- VernacularTitle:二参泽术汤对腹膜淋巴孔的影响及腹水转归机理的研究
- Author:
Shiping DING
;
Jicheng LI
;
Liangen MAO
;
Jian XU
;
Jiandon LIU
- Publication Type:Journal Article
- Keywords:
Peritoneal lymphatic stomata;
Liver cirrhosis;
Nitric oxide;
Drugs,Chinese herbal;
Mice
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To further study the effect of Ershen Zeshu Mixture, a Chinese medicine, on the peritoneal lymphatic stomata and the ascites drainage in experimental mice model of CCl 4-induced fibrosis.By the application of NO supplier (sodium nitroprusside,SNP) and NO suppressor (N G-mononethyl-L-arginine,L-NMMA),the effect of NO on the peritoneal lymphatic stomata and the ascites drainage was studied to clarify the relationship between Ershen Zeshu Mixture and NO in the regulation of the peritoneal lymphatic stomata.METHODS: The mouse model of fibrosis was established with the application of intragastric installations of carbon tetrachloride one time every three days;Scanning electron microscope and computer image processing were used to detect the girth,area and distribution density of the peritoneal lymphatic stomata;the concentration of urinary ions was measured in the experiment.RESULTS: ①Compared to NS group and model group,Ershen Zeshu Mixture could significantly increase the girth and the area of the peritoneal lymphatic stomata,promote its distribution density ( P
