Effects of riboflavin and ascorbic acid on apoptosis and proliferative inhibition of mouse thymocytes induced by deoxynivalenol in vivo
- VernacularTitle:核黄素和抗坏血酸对脱氧雪腐镰刀菌烯醇诱导小鼠胸腺细胞凋亡和增殖抑制影响的研究
- Author:
Yuehong LI
;
Xianghong ZHANG
;
Yongbin YANG
;
Xia YAN
;
Junling WANG
;
Xianghua HUANG
;
Jianzhu YANG
;
Yanli LIU
;
Fengrong WANG
- Publication Type:Journal Article
- Keywords:
Riboflavin;
Ascorbic acid;
Deoxynivalenol;
Apoptosis;
Thymus gland;
Mice
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of riboflavin and ascorbic acid on the apoptosis induced by deoxynivalenol(DON) in mouse thymocytes. METHODS: The effects of riboflavin and ascorbic acid on the apoptosis and proliferation inhibition of thymocytes induced by DON in KM mice were studied with animal experiment, DNA agarose gel electrophoresis and flow cytometric DNA content analysis. RESULTS: Apoptosis rate of thymocytes in DON (4 mg/kg) treated group was 13 73%?1 53% The percentages of apoptosis in riboflavin (1 25 mg/kg-10 mg/kg) and ascorbic acid (25 mg/kg-100 mg/kg) pretreated thymocytes groups were significantly lower than that in DON group ( P
