Rapid effects of dexamethasone on activation of ERK and p38 in HO-8910 cells
- VernacularTitle:地塞米松对人卵巢癌HO-8910细胞ERK和p38活性的快速作用
- Author:
Bing XIA
;
Jian LU
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Human ovarian cancer cell line;
Mitogen-activated protein kinases
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of synthetical glucocorticoid dexamethasone(Dex) on the activation of two members of mitogen-activated protein kinase (MAPK) family, extracellular signal-regulated protein kinase1/2(ERK1/2 ) and p38 MAPK (p38) in human ovarian cancer cell line HO-8910. METHODS: The activation of ERK1/2 and p38 was determined by Western blot. RESULTS: Inhibition of activation of ERK1 and ERK2 by 10 -7 mol/L Dex occurred at 5 min, with maximum up to 41% and 54% respectively at 30 min ( P
