Effect of hyperlipidemia on nitric oxide levels of blood and myocardial tissues in rats
- VernacularTitle:高脂血症对大鼠心肌一氧化氮水平的影响
- Author:
Jun WU
;
Ming SUN
;
Hongyan ZHOU
- Publication Type:Journal Article
- Keywords:
Hyperlipidemia;
Vascular endothelial growth factor;
Nitric oxide;
AngiotensinⅡ;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the impact of hyperlipidemia on vasoactive substances and the mechanism of gemfibrozil in regulating the endothelial function. METHODS: The hyperlipidemic model was established with rats. The serum levels of lipid, NO, angiotensin Ⅱ (Ang Ⅱ), vascular endothelial growth factor(VEGF) and levels of NO, AngⅡ in myocardial tissues were measured. RESULTS: Hyperlipidemic rats had lower level of NO and higher level of VEGF than control subjects. Significant correlation had been shown between serum levels of lipid and NO. Administration of gemfibrozil significantly elevated serum VEGF, NO and myocardial tissue NO levels. CONCLUSIONS: Hyperlipidemia not only reduced serum NO level but also reduced myocardial NO content, which could cause endothelial dysfunction. Gemfibrozil reversed the above changes induced by hyperlipidemia, which might have relevance to VEGF.
