Protective effects of desflurane, sevoflurane and isoflurane preconditioning on myocardium against ischemia-reperfusion injury in rabbits
- VernacularTitle:地氟醚、七氟醚和异氟醚预处理对兔心肌缺血/再灌注损伤的保护作用
- Author:
Zhanglong PENG
;
Yannan HANG
;
Dajin SUN
- Publication Type:Journal Article
- Keywords:
Anesthetics, inhalation;
Ischemic preconditioning, myocondial;
Myocardial reperfusion injury
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0. 5mv. LAD occlusion was maintained for 50min and then released for reperfusion (120min) . Myocardial infarct size was measured by nitroblue tetrazolam at the end of experiment. Results There was no statistically significant difference in HR, MAP, cardiac output (CO), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure ( LVEDP) and rate-pressure products ( RPP) among all groups during ischemia and early reperfusion period except for LVEDP in control group which was much higher than that in all preconditioning groups during the late reperfusion period. Compared with the control group, desflurane, sevoflurane, isoflurane and G+ desflurane reduced myocardial infarct size by 41%, 47%,31.7% and 17.8% respectively without significant homodynamic effects. Myocardial infarct size in G + desflurane groups was significantly larger than that in desflurane group. Conclusion Preconditioning with desflurane, sevoflurane and isoflurane reduce myocardial infarct size in rabbits to some extent. The protective effects may be partly medialed via activation of KATP channel.
