Study on integrin-mediated albumin microbubbles adherence to activated leukocytes
- VernacularTitle:整合素介导微泡声学造影剂与白细胞粘附的实验研究
- Author:
Ying ZHOU
;
Jiang SHAN
;
Yili LIU
;
Xiangdong YOU
;
Qinghu L
- Publication Type:Journal Article
- Keywords:
Integrins;
Leukocytes;
Adhesions
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the mechanism responsible for albumin microbubbles adherence to activated leukocytes. METHODS: In vitro studies were performed in which activated or nonactivated leukocytes were incubated with albumin microbubbles and observed under microscopy. The suspensions of leukocytes and microbubbles which contained or absented of integrins were analyzed with flow cytometry.RESULTS: A minimum of 50 cells were identified under transillumination. 5 min after microbubbles were incubated with leukocytes, the number of cells interacting with microbubbles was greater for activated cells than for nonactivated cells(20 30?2 67 vs 4 50?1 43, P
