Suppression of experimental abdominal aortic aneurysm by tetracycline: a preliminary study
- VernacularTitle:四环素抑制实验性大鼠腹主动脉瘤形成的初步研究
- Author:
Xin ZHAO
;
Zaiping JING
;
Jiang XIONG
- Publication Type:Journal Article
- Keywords:
Aortic aneurysm,abdominal;
Metalloproteinases;
Drug therapy;
Rats
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the mechanism by which tetracycline inhibits the development of experimental abdominal aortic aneurysms (AAA).MethodsMale Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with tetracycline (25?mg/day, subcutaneously; n=10) or with NS alone (n=10). Aortic wall elastin and collagen concentrations were measured with image analysis system and fixed aortic tissues were examined by light microscopy for inflammation. The expression of MMP-2 and MMP-9 were observed in aortic tissues using immunohistochemistry and molecular in situ histohybridization technique. Results AAAs developed in all NS-treated rats, and only 1/10 of tetracycline-treated rats at 14 days(P
