Research on abnormal collagen metabolism of colonic wall in patients with anastomotic leakage
- VernacularTitle:吻合口漏患者结肠组织中基质胶原代谢异常的研究
- Author:
Wei CAO
;
Yiren CHEN
;
Xin JIA
- Publication Type:Journal Article
- Keywords:
Colon;
Surgical procedures,operative;
Leakage, anastomosis;
Collagenases
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between anastomotic leakage of patients undergoing colonic surgery and the collagen metabolism of colonic wall.Method We measured the overall collagen content of colonic tissue by biochemistry and detected the collagen I, III, MMP-1,MMP-13 by immunohistochemistry in 16 patients with anastomotic leakage compared with 16 control cases. Resultthe overall collagen content and collagen I,III of colonic wall in the leakage group were lower than those in the control group (t=3.417,t=2.841, t=2.261,P
