Animal Experiment of Several Kinds of Podophyllotoxin Liposome for Topical Application on Skin
- VernacularTitle:几种鬼臼毒素制剂局部外用的动物实验研究
- Author:
Binbin JIANG
;
Kang ZENG
;
Sanquan ZHANG
;
Ledong SUN
;
Yusheng XIE
- Publication Type:Journal Article
- Keywords:
podophyllotoxin;
liposome;
DPPC;
confocal laser scanning microscope
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the release mode and the amount of retention in skin of podophyllotoxin liposomes in topical application. METHODS: Two kinds of podophyllotoxin liposome suspension (DPPC liposome and bean lecithin liposome) and podophyllotoxin tincture in same concentration were topically applied on the skin of porkets and the amounts of retention of drug in skin of different preparations were detected with confocal laser scanning microscope.RESULTS: The quantity of retention of podophyllotoxin DPPC liposome in epidermis and superficial layer of dermis was larger than those of other two preparations and the drug concentration in applying DPPC liposome kept higher for 48 hours.CONCLUSION:Podophyllotoxin liposome coated by DPPC is much more targetable to skin and is a fairly good topical preparation for applying on skin.
