Effect of Wuling Capsules on IL - 2 and IL - 6 in Healthy Mice and Mice With Immunological Liver Damage
- VernacularTitle:五灵胶囊对正常及免疫性肝损伤小鼠IL-2、IL-6的影响
- Author:
Shengchun WANG
;
Yongwu HU
;
Junqin WANG
- Publication Type:Journal Article
- Keywords:
immune;
IL - 2;
IL - 6;
immunoregulation
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of Wuling capsules on the activities of IL-2 and IL -6 in healthy mice and mice with immunological liver damage .METHODSBALB/C mice were treated with LPS(experimental group)or were not treated (control group) .12 days after giving Wuling capsule ig, the suspension of spleen cells of mice was cultured for 48h and 72h and the supernant fluid was collected for test.The IL - 2 was detected with MTT and IL - 6 with radio - immunoas-say. RESULTS: Wuling capsules could promote Th cells to secret IL- 2 and markedly elevate the liver - damage - induced low level of IL- 2.Wuling capsules did not effect the levels of IL-6 significantly in both healthy mice and mice with liver damage. CONCLUSION: Wuling capsules can promote the secretion of IL-2 and have immunoregulatory actions.
