Preparation and Pharmacokinetic Study of Gastroretentive Slow-released Tinidazole Capsules
- VernacularTitle:替硝唑胃滞留缓释胶囊的制备及药代动力学研究
- Author:
Cangsang SONG
;
Xiaofeng LIU
;
Peiyu WANG
;
Tianqin CHEN
- Publication Type:Journal Article
- Keywords:
gastroretentive slow - released capsule;
in vitro dissolution;
pharmacokinetics
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare gastroretentive slow- released Tinidazole capsules so that the drug can stay at the stomach and act to infective lesions for a long period of time so as to improve the therapeutic efficacy and reduce the adverse reactions.METHODS: The content of Tinidazole was determined by UV - spectrophotometry, the quality standard was established, the stability was studied, the levels of Tinidazole in saliva were detected with HPLC in human body and in vitro dissolubility and human bioavailability were studied .RESULTS: The capsules were stable in quality.The retentive period in artificial gastric juice has reached lOh and in vitro dissolubility(0.5h - 5h) could be described as zero order dissolution .The bioavailability was 163.6% .CONCLUSION: Gastroretentive slow - released Tinidazole capsule was an effective agent for treating HP - related diseases.
