Comparison of Six Methods Ameliorating the Disintegration of Calcium Citrate Tablet
- VernacularTitle:6种改善枸橼酸钙片崩解度的方法比较
- Author:
Wangwen GU
;
Xianwu JIANG
;
Peiqiong XIA
- Publication Type:Journal Article
- Keywords:
calcium citrate;
disintegration;
grain diameter;
tablet
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To compare several METHODS: ameliorating the disintegration of calcium citrate tablet .METHODS: To prepare calcium citrate tablet by six different METHODS: and to determine and evaluate the prepared tablet in respect to the apperance,difference in weight of tablets,hardness,friability and stability .RESULTS:The disintegration was not significantly ameliorated by increasing disintegrant or decreasing lubricant .The hardness was decreased and the friability was increased by decreasing the amount of binder or adding more disintegrant or crushing calcium citrate to powder.The two latter METHODS: increased the difference in weight of tablets.CONCLUSION:The optimal method to ameliorate the disintegration is to diminish the grain diameter and the other parameters of quality is able to be up to the standard.
