Expression of Human Telomerase Reverse Transcriptase in Meningioma and Its Significance
- VernacularTitle:脑膜瘤中人类端粒酶逆转录酶(hTRT)的表达及其意义
- Author:
Guosheng ZHOU
;
Hongyang ZHAO
;
Peng QIAO
- Publication Type:Journal Article
- Keywords:
Meningioma;
Human telomerase reverse transcriptase;
Proliferating cell nuclear antigen
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of human telomerase reverse transcriptase(hTRT) in meningiomas,the correlation with malignancy grade and the prognostic significance of hTRT activity.Methods The expression of hTRT and proliferating cell nuclear antigen(PCNA) in 43 meningiomas was examined by immunohistochemical technique.Postive rates of hTRT between histopathologically different grades were analyzed,and so did between initial detected case group and recurrent case group.The labelling indexes of PCNA between hTRT-positive group and hTRT-negative group were also analysed.Results Of 43 meningiomas examined,19(44%) demonstrated the expression of hTRT.hTRT was present in 3 of 26 benign meningiomas(11 5%),10 of 11 atypical meningiomas(90%) and 6 of 6 malignant meningiomas(100%),respectively(P
