Intervention of Irbesartan in Treatment of Early Diabetic Nephropathy in the Normotensive Aged Patients
- VernacularTitle:伊贝沙坦对血压正常的老年早期糖尿病肾病的干预作用
- Author:
Hua CHEN
- Publication Type:Journal Article
- Keywords:
Irbesartan;
Early diabetic nephropathy;
Microalbuminuria;
Aged
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacies of irbesartan(Irb)in decreasing the 24 hour microalbuminuria(MA)and treating early diabetic nephropathy in the normotensive aged patients.Methods forty-eight normotensive aged patients with the early diabetic nephropathy(24 hour urinary albumin excretion rate within range(20～200?g/min)were divided randomly into two groups: the Irb group(28 cases)and control(C)group(20 cases)were respectively administered with Irb(75～150mmg/d)and placebo. The two group patients were treated with oral antihyperglycemic agents or/and insulin till their fasting blood glucose(FBG) value ≤7 0mmol/L and postprandial 2 hour blood glucose(2hBG) level ≤10 0mmol/L.The MA, systolic and diastolic pressure(SBP and DBP), serum creatinine(Cr)and uric acid(UA)and potassium(K +) levels were examined before and after the treatment(at the 12 th wk and 24 th wk).Results After treatment ,the MA of the Irb groups was significantly decreased(P
