Expression and significance of smad_4mRNA,TGF-?_1 ,and TGF-?R_1 in pancreatic carcinoma
- VernacularTitle:胰腺癌组织s mad_4m RNA,TGF-?_1和TGF-?R_1的表达及意义
- Author:
Zhongcheng HUANG
;
Zhulin YANG
;
Yongguo LI
;
Dewu ZHONG
;
Qunwei WANG
;
Shengfu HUANG
- Publication Type:Journal Article
- Keywords:
PANCREATIC NEPLASMS/genet;
ADENOCARCINOMA/genet;
TRANSFORMING GROWTH FACTOR BETA;
GENES,SUPPRESSOR,TUMOR
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of expressions of smad_4mRNA,TGF-?_1, and TGF-?R_1 in pancreatic carcinoma(PC) . Methods Smad_4mRNA was detected by in situ hybridization. TGF-?_1 and TGF-?R_1 were detected by immunohistochemical method. Results The positive rates of smad_4mRNA,TGF-?_1 and TGF-?R_1 were singnificantly lower in 53 slices of pancreatic carcinoma than those in 25 slices of paracancerous tissue (all P
